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Our in vitro effects recommend that EAM-2201 ought to be examined when it comes to opportunity in vivo pharmacokinetic drug–drug interactions a result of time-dependent inhibition of CYP2C8, CYP2C9, CYP2C19 and CYP3A4 actions and aggressive inhibition of UGT1A3 exercise.ED50 values were being considered significantly different if the ninety five%

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